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Antiosteoporotic activity of anthraquinones from Morinda officinalis on osteoblasts and osteoclasts.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2009 Jan 23; Vol. 14 (1), pp. 573-83. Date of Electronic Publication: 2009 Jan 23. - Publication Year :
- 2009
-
Abstract
- Bioactivity-guided fractionation led to the successful isolation of antiosteoporotic components, i.e. physicion (1), rubiadin-1-methyl ether (2), 2-hydroxy-1-methoxy- anthraquinone (3), 1,2-dihydroxy-3-methylanthraquinone (4), 1,3,8-trihydroxy-2-methoxy- anthraquinone (5), 2-hydroxymethyl-3-hydroxyanthraquinone (6), 2-methoxyanthraquinone (7) and scopoletin (8) from an ethanolic extract of the roots of Morinda officinalis. Compounds 4-8 are isolated for the first time from M. officinalis. Among them, compounds 2 and 3 promoted osteoblast proliferation, while compounds 4, 5 increased osteoblast ALP activity. All of the isolated compounds inhibited osteoclast TRAP activity and bone resorption, and the inhibitory effects on osteoclastic bone resorption of compounds 1 and 5 were stronger than that of other compounds. Taken together, antiosteoporotic activity of M. officinalis and its anthraquinones suggest therapeutic potential against osteoporosis.
- Subjects :
- Alkaline Phosphatase metabolism
Animals
Anthraquinones therapeutic use
Bone Density Conservation Agents therapeutic use
Bone Resorption drug therapy
Cell Proliferation drug effects
Cells, Cultured
Molecular Structure
Osteoblasts cytology
Osteoclasts cytology
Rats
Rats, Wistar
Anthraquinones chemistry
Anthraquinones pharmacology
Bone Density Conservation Agents chemistry
Bone Density Conservation Agents pharmacology
Morinda chemistry
Osteoblasts drug effects
Osteoclasts drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 19169204
- Full Text :
- https://doi.org/10.3390/molecules14010573