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A novel class of allosteric modulators of AMPA/Kainate receptors.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Feb 15; Vol. 19 (4), pp. 1254-7. Date of Electronic Publication: 2008 Dec 30. - Publication Year :
- 2009
-
Abstract
- The rapid hydrolysis in vivo of IDRA21 to 2-amino-5-chlorobenzensulfonamide has been demonstrated by microdialysis experiments. The IDRA21 metabolite possess in vitro a biological activity similar to that of IDRA21 itself. Taking 2-amino-5-chlorobenzensulfonamide as lead compound, a novel class of AMPAR positive allosteric modulators has been prepared.
- Subjects :
- Administration, Oral
Animals
Benzothiadiazines chemistry
Combinatorial Chemistry Techniques
Hippocampus drug effects
Molecular Structure
Rats
Sulfonamides chemistry
Benzenesulfonamides
Benzothiadiazines pharmacology
Models, Molecular
Receptors, AMPA drug effects
Receptors, Kainic Acid drug effects
Sulfonamides chemical synthesis
Sulfonamides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 19
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 19162477
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.12.094