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[Significance of isolated anti-HBs antibodies in subjects not vaccinated against hepatitis B viruses].
- Source :
-
Gastroenterologie clinique et biologique [Gastroenterol Clin Biol] 1991; Vol. 15 (6-7), pp. 477-80. - Publication Year :
- 1991
-
Abstract
- The significance of isolated anti-HBs antibodies in subjects not vaccinated against the hepatitis B virus (HBV) was investigated in 13 healthy blood donors. All were European and none had any risk factor for hepatitis B infection. Serological assays included HBV-DNA and anti-preS 2 antibody determinations which were all negative. After injection with hepatitis B vaccine (Hevac B), only one out of the 13 subjects exhibited an anamnestic response in favor of secondary immunization. Neutralization tests for serum anti-HBs antibody were positive in only 6 subjects. Our data suggest that in most cases isolated anti-HBs positivity does not correspond to true antibody; booster injection of HBV vaccine seems to be the best way of verifying that antibodies are really protective.
- Subjects :
- Adult
DNA, Viral analysis
Female
Hepatitis B drug therapy
Hepatitis B genetics
Hepatitis B virus genetics
Humans
Immunoenzyme Techniques
Male
Middle Aged
Radioimmunoassay
Hepatitis B immunology
Hepatitis B Antibodies analysis
Hepatitis B virus immunology
Viral Hepatitis Vaccines administration & dosage
Subjects
Details
- Language :
- French
- ISSN :
- 0399-8320
- Volume :
- 15
- Issue :
- 6-7
- Database :
- MEDLINE
- Journal :
- Gastroenterologie clinique et biologique
- Publication Type :
- Academic Journal
- Accession number :
- 1916124