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Polyacrylamide-grafted-alginate-based pH-sensitive hydrogel beads for delivery of ketoprofen to the intestine: in vitro and in vivo evaluation.
- Source :
-
Journal of biomaterials science. Polymer edition [J Biomater Sci Polym Ed] 2009; Vol. 20 (2), pp. 235-51. - Publication Year :
- 2009
-
Abstract
- A pH-sensitive graft co-polymer of polyacrylamide (PAAm) and sodium alginate (SA) was synthesized by free radical polymerization under a nitrogen atmosphere followed by alkaline hydrolysis. The co-polymer was characterized by Fourier transform infrared (FT-IR) spectroscopy, elemental analysis and thermogravimetric analysis (TGA). Ketoprofen-loaded graft co-polymer beads were prepared by ionotropic gelation/covalent cross-linking. The beads were characterized by swelling studies, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). A pulsatile swelling study indicated that the co-polymer exhibits considerable pH-sensitive behavior. Release of ketoprofen was significantly increased when the pH of the medium was changed from acidic to alkaline. Stomach histopathology of albino rats indicated that the beads were able to retard the release of the drug in the stomach, and gastric side-effects like ulceration, hemorrhage and erosion of gastric mucosa were diminished when the drug was entrapped into PAAm-g-SA-based pH-sensitive hydrogel beads.
- Subjects :
- Acrylic Resins administration & dosage
Alginates administration & dosage
Animals
Anti-Inflammatory Agents, Non-Steroidal chemistry
Calorimetry, Differential Scanning
Gastric Mucosa metabolism
Histocytochemistry
Hydrogels administration & dosage
Intestines drug effects
Ketoprofen chemistry
Male
Microscopy, Electron, Scanning
Particle Size
Rats
Spectroscopy, Fourier Transform Infrared
Stomach drug effects
Acrylic Resins chemistry
Alginates chemistry
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Drug Delivery Systems
Hydrogels chemistry
Intestinal Mucosa metabolism
Ketoprofen administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0920-5063
- Volume :
- 20
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of biomaterials science. Polymer edition
- Publication Type :
- Academic Journal
- Accession number :
- 19154672
- Full Text :
- https://doi.org/10.1163/156856209X404514