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Enhanced insulin secretory response to acetylcholine by perifused pancreas of 5-day-old preobese Zucker rats.
- Source :
-
Endocrinology [Endocrinology] 1991 Oct; Vol. 129 (4), pp. 2219-24. - Publication Year :
- 1991
-
Abstract
- The insulin secretion rate in response to different secretagogues and neurotransmittors was studied in perifused pancreas of 5-day-old lean (Fa/Fa) and preobese (fa/fa) Zucker rats. Glucose (16.6 mM) alone or in combination with 20 mM arginine or 5 mM theophylline induced a net stimulation of insulin secretion. This effect was similar in the two groups. By contrast, the stimulatory effect of acetylcholine on glucose-induced insulin secretion was significantly higher in preobese pups than in lean rats. There was also a tendency toward a higher inhibitory effect of norepinephrine on insulin secretion in preobese than in lean rats, but this difference did not reach statistical significance. Together these results demonstrate a normal insulin secretion in response to nutrient secretagogues in preobese fa/fa rats but an enhanced effect of acetylcholine. This latter effect may be related to the changes in the autonomic nervous system activity, which is usually described in obese fa/fa rats.
- Subjects :
- Animals
Arginine pharmacology
Disease Susceptibility metabolism
Glucose pharmacology
Insulin Secretion
Norepinephrine pharmacology
Obesity metabolism
Perfusion
Rats
Theophylline pharmacology
Acetylcholine pharmacology
Animals, Newborn metabolism
Insulin metabolism
Pancreas metabolism
Rats, Zucker metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0013-7227
- Volume :
- 129
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 1915103
- Full Text :
- https://doi.org/10.1210/endo-129-4-2219