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Photopolymerization of methacrylated chitosan/PNIPAAm hybrid dual-sensitive hydrogels as carrier for drug delivery.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2009 Apr 01; Vol. 44 (3), pp. 229-35. Date of Electronic Publication: 2008 Dec 25. - Publication Year :
- 2009
-
Abstract
- A series of hybrid hydrogels based on glycidyl methacrylated chitosan (CS-GMA) and N-isopropylacrylamide (NIPAAm) were designed and prepared via photopolymerization technology. The hydrogels were characterized by Fourier transform infrared (FT-IR), differential scanning calorimetry (DSC) and optical transmittance. The interior morphology of hydrogels was investigated by scanning electron microscopy (SEM). The swelling experiment results revealed that hybrid hydrogel exhibited combined pH and temperature sensitivities. Acid orange 8 (AO8) and 5-flurouracil (5-Fu) were selected as model drugs for examining their release from hydrogels. The results suggested that hydrogel composition and pH value of buffer solution had great influences on release profiles.
- Subjects :
- Acridine Orange chemistry
Acrylamides chemistry
Acrylic Resins
Calorimetry, Differential Scanning
Chitosan chemical synthesis
Chitosan chemistry
Fluorouracil chemistry
Hydrogen-Ion Concentration
Kinetics
Microscopy, Electron, Scanning
Phase Transition
Polymers chemistry
Spectroscopy, Fourier Transform Infrared
Temperature
Acrylamides radiation effects
Chitosan analogs & derivatives
Chitosan radiation effects
Drug Carriers chemistry
Drug Delivery Systems
Hydrogels chemistry
Light
Polymers radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 44
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 19146871
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2008.12.009