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Immunologic evaluation of patients with recurrent ear, nose, and throat infections.
- Source :
-
American journal of otolaryngology [Am J Otolaryngol] 2008 Nov-Dec; Vol. 29 (6), pp. 385-92. Date of Electronic Publication: 2008 Jun 16. - Publication Year :
- 2008
-
Abstract
- Purpose: In this study, we aimed to study the frequency of possible underlying immunodeficiency responsible for susceptibility to ear, nose, and throat (ENT) infection.<br />Materials and Methods: One hundred three (72 males and 31 females) consecutive children and adult patients with history of recurrent or chronic ENT infections, referred by otolaryngologists to the Department of Allergy and Clinical Immunology, Children's Medical Center, Tehran University of Medical Sciences (Tehran, Iran), were enrolled to the study from March 2003 to March 2006. For each patient, demographic information and medical histories of any ENT infections were collected by reviewing the patient's records. We measured immunoglobulin isotype concentrations and immunoglobulin (Ig) G subclasses by nephelometry and enzyme-linked immunosorbent assay methods, respectively. Of 103 patients, 75 received unconjugated pneumococcus polyvalent vaccine, and blood samples were taken before and 21 days after vaccination. Specific antibodies against whole pneumococcal antigens were measured using enzyme-linked immunosorbent assay method. Existence of bronchiectasis was confirmed in each patient using high resolution computed tomography scan.<br />Results: Among 103 patients, 17 (16.5%) patients were diagnosed to have defects in antibody-mediated immunity including 6 patients with immunoglobulin class deficiency (2 common variable deficiency and 4 IgA deficiency), 3 with IgG subclass deficiency (2 IgG2 and 1 IgG3), and 8 with specific antibody deficiency against polysaccharide antigens. In our series, bronchiectasis was detected in 5 cases associated with primary immunodeficiency.<br />Conclusions: Long-standing history of ENT infections could be an alarm for ENT infections associated with primary antibody deficiency.
- Subjects :
- Adolescent
Adult
Aged
Case-Control Studies
Child
Child, Preschool
Female
Follow-Up Studies
Humans
IgA Deficiency diagnosis
IgA Deficiency epidemiology
IgG Deficiency diagnosis
IgG Deficiency epidemiology
Immunologic Deficiency Syndromes epidemiology
Incidence
Iran epidemiology
Male
Middle Aged
Monitoring, Immunologic
Otitis Media epidemiology
Pharyngitis epidemiology
Recurrence
Rhinitis epidemiology
Risk Assessment
Severity of Illness Index
Surveys and Questionnaires
Young Adult
Immunologic Deficiency Syndromes diagnosis
Otitis Media immunology
Pharyngitis immunology
Rhinitis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-818X
- Volume :
- 29
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- American journal of otolaryngology
- Publication Type :
- Academic Journal
- Accession number :
- 19144299
- Full Text :
- https://doi.org/10.1016/j.amjoto.2007.11.007