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Freund's vaccine adjuvant promotes Her2/neu breast cancer.
- Source :
-
BMC cancer [BMC Cancer] 2009 Jan 14; Vol. 9, pp. 19. Date of Electronic Publication: 2009 Jan 14. - Publication Year :
- 2009
-
Abstract
- Background: Inflammation has been linked to the etiology of many organ-specific cancers. Indirect evidence suggests a possible role for inflammation in breast cancer. We investigated whether the systemic inflammation induced by Freund's adjuvant (FA) promotes mammary carcinogenesis in a rat model in which cancer is induced by the neu oncogene.<br />Methods: The effects of FA on hyperplastic mammary lesions and mammary carcinomas were determined in a neu-induced rat model. The inflammatory response to FA treatment was gauged by measuring acute phase serum haptoglobin. In addition, changes in cell proliferation and apoptosis following FA treatment were assessed.<br />Results: Rats receiving FA developed twice the number of mammary carcinomas as controls. Systemic inflammation following FA treatment is chronic, as shown by a doubling of the levels of the serum biomarker, haptoglobin, 15 days following initial treatment. We also show that this systemic inflammation is associated with the increased growth of hyperplastic mammary lesions. This increased growth results from a higher rate of cellular proliferation in the absence of changes in apoptosis.<br />Conclusion: Our data suggests that systemic inflammation induced by Freund's adjuvant (FA) promotes mammary carcinogenesis. It will be important to determine whether adjuvants currently used in human vaccines also promote breast cancer.
- Subjects :
- Animals
Cell Proliferation drug effects
Female
Rats
Rats, Wistar
Adjuvants, Immunologic adverse effects
Freund's Adjuvant adverse effects
Genes, erbB-2 drug effects
Mammary Neoplasms, Experimental genetics
Mammary Neoplasms, Experimental pathology
Sepsis chemically induced
Sepsis complications
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 19144184
- Full Text :
- https://doi.org/10.1186/1471-2407-9-19