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Survival analysis of 97 cats with nasal lymphoma: a multi-institutional retrospective study (1986-2006).
- Source :
-
Journal of veterinary internal medicine [J Vet Intern Med] 2009 Mar-Apr; Vol. 23 (2), pp. 287-94. Date of Electronic Publication: 2009 Jan 02. - Publication Year :
- 2009
-
Abstract
- Background: Feline nasal lymphoma (NLSA) is a condition for which no standard of care exists.<br />Hypothesis: There is no difference in survival times of cats with NLSA treated with single or multimodality therapy.<br />Animals: Records from 97 cats diagnosed with NLSA were examined.<br />Methods: The purpose of this retrospective study was to compare the survival times of cats with NLSA treated with radiation therapy (RT) alone, chemotherapy alone, or RT + chemotherapy and identify potential prognostic variables that affected survival. Cats were grouped according to therapy: RT + chemotherapy (n = 60), RT alone (n = 19), or chemotherapy alone (n = 18).<br />Results: Survival was calculated with 2 methods. The 1st survival analysis (method A) included all cats, but counted only deaths caused by progressive NLSA. The median survival time (MST), regardless of therapy modality, was 536 days. The 2nd survival analysis (method B) also included all cats and counted all deaths, regardless of cause, as events. The overall MST calculated for all deaths was 172 days. A negative independent prognostic variable identified was anemia (P < .001), and positive independent prognostic variables were a complete response to therapy (P < .001) and total radiation dose >32 Gy (P= .03).<br />Conclusions and Clinical Importance: There were no significant differences in survival times among the 3 treatment groups but these results suggest that the addition of higher doses of RT to a cat's treatment protocol may control local disease and therefore influence survival.
- Subjects :
- Animals
Cat Diseases drug therapy
Cat Diseases radiotherapy
Cats
Combined Modality Therapy veterinary
Female
Lymphoma drug therapy
Lymphoma mortality
Lymphoma radiotherapy
Male
Nose Neoplasms drug therapy
Nose Neoplasms mortality
Nose Neoplasms radiotherapy
Retrospective Studies
Survival Rate
Treatment Outcome
Cat Diseases mortality
Lymphoma veterinary
Nose Neoplasms veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 0891-6640
- Volume :
- 23
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of veterinary internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 19143934
- Full Text :
- https://doi.org/10.1111/j.1939-1676.2008.0243.x