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Remote neuroimmune signaling: a long-range mechanism of nociceptive network plasticity.
- Source :
-
Trends in neurosciences [Trends Neurosci] 2009 Feb; Vol. 32 (2), pp. 110-7. Date of Electronic Publication: 2009 Jan 08. - Publication Year :
- 2009
-
Abstract
- Chronic pain secondary to neuronal injury is actively and continuously modulated at multiple locations along the sensory neuraxis. Here, we describe how nociceptive neurons of the spinal cord and thalamus process and communicate nociceptive information in terms of precisely calibrated firing patterns. We then discuss how several cell types with immunogenic properties (e.g. blood cells and glia) cause system-wide interference in nociceptive processing through novel signaling schema, thus contributing to nociceptive network plasticity and chronic pain.
- Subjects :
- Animals
Central Nervous System cytology
Gliosis immunology
Gliosis physiopathology
Humans
Lymphocyte Activation immunology
Microglia immunology
Neuronal Plasticity physiology
Signal Transduction physiology
Central Nervous System physiology
Nerve Net physiology
Neuroimmunomodulation physiology
Nociceptors physiology
Pain physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0166-2236
- Volume :
- 32
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Trends in neurosciences
- Publication Type :
- Academic Journal
- Accession number :
- 19135730
- Full Text :
- https://doi.org/10.1016/j.tins.2008.11.004