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Evidence of linkage in a Hispanic cohort with a Class III dentofacial phenotype.
- Source :
-
Journal of dental research [J Dent Res] 2009 Jan; Vol. 88 (1), pp. 56-60. - Publication Year :
- 2009
-
Abstract
- Despite the prevalence of craniofacial disorders, the genetic contribution remains poorly understood. Class III malocclusion represents a specific craniofacial problem that can be handicapping, both functionally and socially. We hypothesized that the Class III phenotype is genetically linked to specific loci that regulate maxillary or mandibular growth. To determine the region linked to the Class III phenotype in four Hispanic families, we performed a genome-wide scan and linkage analysis using 500 microsatellite markers. Pedigree and linkage analyses revealed that the Class III phenotype (primarily maxillary deficiency) segregates in an autosomal-dominant manner, and that 5 loci (1p22.1, 3q26.2, 11q22, 12q13.13, and 12q23) are suggestive of linkage. Candidate genes within the 12q23 region (ZLR=2.93) include IGF1, HOXC, and COL2A1. Chromosome 1 results (ZLR=2.92) were similar to those reported previously in an Asian cohort with mandibular prognathism, suggesting that a common upstream genetic element may be responsible for both mandibular prognathism and maxillary deficiency.
- Subjects :
- Adolescent
Adult
Aged
Cephalometry
Child
Chromosome Mapping
Chromosomes, Human, Pair 1 genetics
Chromosomes, Human, Pair 11 genetics
Chromosomes, Human, Pair 12 genetics
Chromosomes, Human, Pair 3 genetics
Cohort Studies
Collagen Type II genetics
Female
Genes, Homeobox genetics
Humans
Insulin-Like Growth Factor I genetics
Male
Maxilla abnormalities
Microsatellite Repeats genetics
Middle Aged
Pedigree
Penetrance
Phenotype
Young Adult
Genetic Linkage genetics
Hispanic or Latino genetics
Malocclusion, Angle Class III genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1544-0591
- Volume :
- 88
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of dental research
- Publication Type :
- Academic Journal
- Accession number :
- 19131318
- Full Text :
- https://doi.org/10.1177/0022034508327817