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Preliminary evaluation of pharmacological properties of some xanthone derivatives.
- Source :
-
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2009 Feb 01; Vol. 17 (3), pp. 1345-52. Date of Electronic Publication: 2008 Dec 24. - Publication Year :
- 2009
-
Abstract
- A series of xanthone derivatives were synthesized and examined for electrocardiographic, antiarrhythmic, hypotensive and anticonvulsant activities as well as for alpha(1)- and beta(1)-adrenergic binding affinities. Among the investigated compounds, some of them exhibited significant antiarrhythmic and/or hypotensive activity. The data obtained via receptor binding assay are in agreement with pharmacological results and could explain antiarrhythmic and/or hypotensive activity of the newly synthesized structures.
- Subjects :
- Adrenergic alpha-1 Receptor Antagonists
Adrenergic alpha-2 Receptor Antagonists
Animals
Anti-Arrhythmia Agents chemical synthesis
Anti-Arrhythmia Agents chemistry
Anticonvulsants chemistry
Anticonvulsants toxicity
Antihypertensive Agents chemical synthesis
Antihypertensive Agents chemistry
Electrocardiography
Kinetics
Male
Mice
Rats
Rats, Wistar
Receptors, Adrenergic, alpha-1 metabolism
Receptors, Adrenergic, alpha-2 metabolism
Seizures chemically induced
Xanthones chemical synthesis
Xanthones chemistry
Anti-Arrhythmia Agents pharmacology
Anticonvulsants pharmacology
Antihypertensive Agents pharmacology
Xanthones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3391
- Volume :
- 17
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 19131251
- Full Text :
- https://doi.org/10.1016/j.bmc.2008.12.031