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S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor.

Authors :
Li MH
Sanchez T
Yamase H
Hla T
Oo ML
Pappalardo A
Lynch KR
Lin CY
Ferrer F
Source :
Cancer letters [Cancer Lett] 2009 Apr 18; Vol. 276 (2), pp. 171-9. Date of Electronic Publication: 2009 Jan 07.
Publication Year :
2009

Abstract

Sphingosine-1-phosphate (S1P) is an important regulator of cellular functions via interaction with its receptors S1P(1-5). To date, nothing is known about the S1P receptor expression and the effects of S1P signaling in Wilms tumor. In this study, we found ubiquitous expression of S1P receptors in Wilms tumor specimens and cell lines. We demonstrated that S1P(1) acted as a promigratory modulator by employing S1P(1) antagonist VPC44116, S1P(1) siRNA and adenoviral transduction in Wilms tumor cells. Further, we clarified that S1P(1)-mediated migration occurred via Gi coupling and activation of PI3K and Rac1. In addition, S1P stimulated WiT49 cell invasion through S1P(1)/Gi signaling pathway. We consider that targeting S1P(1) may be a point of therapeutic intervention in Wilms tumor.

Details

Language :
English
ISSN :
1872-7980
Volume :
276
Issue :
2
Database :
MEDLINE
Journal :
Cancer letters
Publication Type :
Academic Journal
Accession number :
19131156
Full Text :
https://doi.org/10.1016/j.canlet.2008.11.025