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A novel mouse model of Ureaplasma-induced perinatal inflammation: effects on lung and brain injury.
- Source :
-
Pediatric research [Pediatr Res] 2009 Apr; Vol. 65 (4), pp. 430-6. - Publication Year :
- 2009
-
Abstract
- Chorioamnionitis is associated with increased lung and brain injury in premature infants. Ureaplasma is the microorganisms most frequently associated with preterm birth. Whether Ureaplasma-induced antenatal inflammation worsens lung and brain injury is unknown. We developed a mouse model combining antenatal Ureaplasma infection and postnatal oxygen exposure. Intraamniotic Ureaplasma Parvum (UP) increased proinflammatory cytokines in placenta and fetal lungs. Antenatal exposure to UP or broth caused mild postnatal inflammation and worsened oxygen-induced lung injury. Antenatal UP exposure induced central microgliosis and disrupted brain development as detected by decreased number of calbindin-positive and calretinin-positive neurons in the neocortex. Postnatal oxygen decreased calretinin-positive neurons in the neocortex but combined with antenatal UP exposure did not worsen brain injury. Antenatal inflammation exacerbates the deleterious effects of oxygen on lung development, but the broth effects prohibit concluding that UP by itself is a compounding risk factor for bronchopulmonary dysplasia. In contrast, antenatal UP-induced inflammation alone is sufficient to disturb brain development. This model may be helpful in exploring the pathophysiology of perinatal lung and brain injury to develop new protective strategies.
- Subjects :
- Animals
Animals, Newborn
Brain immunology
Brain pathology
Brain Diseases immunology
Brain Diseases pathology
Bronchopulmonary Dysplasia immunology
Bronchopulmonary Dysplasia pathology
Chorioamnionitis immunology
Chorioamnionitis pathology
Cytokines metabolism
Disease Models, Animal
Female
Humans
Hyperoxia complications
Infant, Newborn
Lung immunology
Lung pathology
Mice
Pregnancy
Ureaplasma Infections immunology
Ureaplasma Infections microbiology
Ureaplasma Infections pathology
Brain microbiology
Brain Diseases microbiology
Bronchopulmonary Dysplasia microbiology
Chorioamnionitis microbiology
Lung microbiology
Ureaplasma pathogenicity
Ureaplasma Infections complications
Subjects
Details
- Language :
- English
- ISSN :
- 1530-0447
- Volume :
- 65
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Pediatric research
- Publication Type :
- Academic Journal
- Accession number :
- 19127208
- Full Text :
- https://doi.org/10.1203/PDR.0b013e31819984ce