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Reducing the number of reader interpretations in MRMC studies.
- Source :
-
Academic radiology [Acad Radiol] 2009 Feb; Vol. 16 (2), pp. 209-17. - Publication Year :
- 2009
-
Abstract
- Rationale and Objectives: Multireader, multicase (MRMC) receiver-operating characteristic studies often require large numbers of patients, readers, and reader interpretations. The objective of this work is to evaluate a new "mixed" MRMC study design that reduces the number of reader interpretations.<br />Materials and Methods: As compared to the traditional MRMC design, the number of reader interpretations and the number of cases that must be truth-verified for the new mixed design was evaluated theoretically and empirically for various correlation values and sample sizes.<br />Results: For large MRMC studies, the new mixed design offers a substantial savings in the number of reader interpretations if the magnitude of the difference in between-reader correlations is not zero. For example, compared to a traditional design with 20 readers, 200 total cases, and a difference in between-reader correlations of 0.05, the newly proposed mixed design requires each reader to interpret only 132 cases, but at a cost of truth-verifying an additional 64 cases.<br />Conclusions: The mixed design can reduce the number of cases that readers need to interpret and the overall duration of a study, but at a cost in terms of the number of cases that must be truth-verified. The mixed design is particularly useful for studies where the condition being detected is not rare and patients routinely undergo the gold standard assessment.
Details
- Language :
- English
- ISSN :
- 1878-4046
- Volume :
- 16
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Academic radiology
- Publication Type :
- Academic Journal
- Accession number :
- 19124107
- Full Text :
- https://doi.org/10.1016/j.acra.2008.05.014