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Breast cancer incidence after hormonal infertility treatment in Sweden: a cohort study.

Authors :
Orgéas CC
Sanner K
Hall P
Conner P
Holte J
Nilsson SJ
Sundfeldt K
Persson I
Chia KS
Wedren S
Dickman PW
Czene K
Source :
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2009 Jan; Vol. 200 (1), pp. 72.e1-7.
Publication Year :
2009

Abstract

Objective: To assess the impact of infertility treatment with causes of infertility on incidence of breast cancer.<br />Study Design: Historical prospective cohort study of 1135 women attending major university clinics for treatment of infertility in Sweden, 1961-1976. Women were classified as users of clomiphene citrate or gonadotropins, or a combination of both therapies. Standardized incidence ratios were calculated to estimate relative risk of breast cancer.<br />Results: We observed 54 cases of breast cancer during 1961-2004, which did not significantly exceed those expected. Users of high-dose clomiphene citrate had an almost 2-fold increased risk (standardized incidence ratio, 1.90; 95% confidence interval, 1.08-3.35). This association was more pronounced among women referred for nonovulatory factors, with 3-fold increased risk (standardized incidence ratio, 3.00; 95% confidence interval, 1.35-6.67).<br />Conclusion: No overall increased risk for breast cancer was shown with infertility treatment. Women with nonovulatory causes treated with high-dose clomiphene citrate therapy may have an elevated risk for breast cancer.

Details

Language :
English
ISSN :
1097-6868
Volume :
200
Issue :
1
Database :
MEDLINE
Journal :
American journal of obstetrics and gynecology
Publication Type :
Academic Journal
Accession number :
19121659
Full Text :
https://doi.org/10.1016/j.ajog.2008.08.066