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Breast cancer incidence after hormonal infertility treatment in Sweden: a cohort study.
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2009 Jan; Vol. 200 (1), pp. 72.e1-7. - Publication Year :
- 2009
-
Abstract
- Objective: To assess the impact of infertility treatment with causes of infertility on incidence of breast cancer.<br />Study Design: Historical prospective cohort study of 1135 women attending major university clinics for treatment of infertility in Sweden, 1961-1976. Women were classified as users of clomiphene citrate or gonadotropins, or a combination of both therapies. Standardized incidence ratios were calculated to estimate relative risk of breast cancer.<br />Results: We observed 54 cases of breast cancer during 1961-2004, which did not significantly exceed those expected. Users of high-dose clomiphene citrate had an almost 2-fold increased risk (standardized incidence ratio, 1.90; 95% confidence interval, 1.08-3.35). This association was more pronounced among women referred for nonovulatory factors, with 3-fold increased risk (standardized incidence ratio, 3.00; 95% confidence interval, 1.35-6.67).<br />Conclusion: No overall increased risk for breast cancer was shown with infertility treatment. Women with nonovulatory causes treated with high-dose clomiphene citrate therapy may have an elevated risk for breast cancer.
- Subjects :
- Adult
Breast Neoplasms epidemiology
Chorionic Gonadotropin therapeutic use
Clomiphene therapeutic use
Cohort Studies
Female
Fertility Agents, Female therapeutic use
Humans
Incidence
Prospective Studies
Sweden epidemiology
Breast Neoplasms chemically induced
Chorionic Gonadotropin adverse effects
Clomiphene adverse effects
Fertility Agents, Female adverse effects
Infertility, Female drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6868
- Volume :
- 200
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 19121659
- Full Text :
- https://doi.org/10.1016/j.ajog.2008.08.066