The expression of the novel CYP2W1 enzyme is an independent prognostic factor in colorectal cancer - a pilot study.

Authors :: Edler D
Stenstedt K
Ohrling K
Hallström M
Karlgren M
Ingelman-Sundberg M
Ragnhammar P
Source :: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2009 Mar; Vol. 45 (4), pp. 705-12. Date of Electronic Publication: 2008 Dec 30.
Publication Year :: 2009
Abstract: Aim: Cytochrome P450 (CYP) enzymes are important for drug metabolism. A novel cytochrome P450 enzyme, CYP2W1, has recently been identified. This enzyme is mainly found in foetal colon tissue and in tumour tissue. In this pilot study, we have investigated the expression of CYP2W1 in 162 tumours from patients with stages II and III colorectal cancer.<br />Methods: The expression of CYP2W1 enzyme was immunohistochemically detected using a polyclonal antibody. Staining intensity was defined using a visual grading scale from 0 to 3. Grades 0-2 were classified as low, and grade 3 was classified as high expression of CYP2W1.<br />Results: About 64% of the tumours expressed a low level of CYP2W1-expression, and 36% expressed a high level. CYP2W1-expression was an independent prognostic factor for overall survival (p=0.007), where a high expression was associated with a worse clinical outcome.<br />Conclusions: Immunohistochemically assessed expression of CYP2W1 is an independent prognostic factor in patients with stages II and III colorectal cancer.

Subjects :: Adult
Aged
Colorectal Neoplasms pathology
Colorectal Neoplasms surgery
Cytochrome P450 Family 2
Female
Humans
Male
Microscopy, Fluorescence
Middle Aged
Neoplasm Proteins metabolism
Neoplasm Staging
Pilot Projects
Prognosis
Survival Analysis
Treatment Outcome
Biomarkers, Tumor metabolism
Colorectal Neoplasms enzymology
Cytochrome P-450 Enzyme System metabolism

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