Effect of liposomal tetracycline hydrochloride on enzymatic function of the liver.

Authors :: Tikhonov SN
Rotov KA
Khrapova NP
Alekseev VV
Snatenkov EA
Zamarin AA
Simakova NA
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2008 Apr; Vol. 145 (4), pp. 443-5.
Publication Year :: 2008
Abstract: Preparation and physicochemical properties of liposome-incorporated tetracycline are described. Comparison of the effects of tetracycline hydrochloride in free and liposome-incorporated forms on enzymatic functions of the liver showed that immobilization of the antibiotic into liposomes protects liver cells from functional disturbances.

Subjects :: Adenosine Triphosphatases metabolism
Alkaline Phosphatase metabolism
Animals
Animals, Outbred Strains
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents pharmacology
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Liposomes
Liver Extracts metabolism
Liver Function Tests
Mice
Phosphorylases metabolism
Tetracycline administration & dosage
Time Factors
Liver drug effects
Liver enzymology
Tetracycline pharmacology

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