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Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.
- Source :
-
Trends in pharmacological sciences [Trends Pharmacol Sci] 2009 Feb; Vol. 30 (2), pp. 85-94. Date of Electronic Publication: 2008 Dec 26. - Publication Year :
- 2009
-
Abstract
- Curcumin (diferuloylmethane), a yellow pigment in the spice turmeric (also called curry powder), has been used for centuries as a treatment for inflammatory diseases. Extensive research within the past two decades has shown that curcumin mediates its anti-inflammatory effects through the downregulation of inflammatory transcription factors (such as nuclear factor kappaB), enzymes (such as cyclooxygenase 2 and 5 lipoxygenase) and cytokines (such as tumor necrosis factor, interleukin 1 and interleukin 6). Because of the crucial role of inflammation in most chronic diseases, the potential of curcumin has been examined in neoplastic, neurological, cardiovascular, pulmonary and metabolic diseases. The pharmacodynamics and pharmacokinetics of curcumin have been examined in animals and in humans. Various pharmacological aspects of curcumin in vitro and in vivo are discussed in detail here.
- Subjects :
- Animals
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Chronic Disease
Curcuma
Drug Delivery Systems
Humans
Antioxidants administration & dosage
Antioxidants pharmacology
Antioxidants therapeutic use
Curcumin administration & dosage
Curcumin pharmacology
Curcumin therapeutic use
Inflammation drug therapy
Phytotherapy
Spices
Subjects
Details
- Language :
- English
- ISSN :
- 0165-6147
- Volume :
- 30
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Trends in pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 19110321
- Full Text :
- https://doi.org/10.1016/j.tips.2008.11.002