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Keeping autoimmunity in check: how to control a Th17 cell controller.
- Source :
-
Immunity [Immunity] 2008 Dec 19; Vol. 29 (6), pp. 841-3. - Publication Year :
- 2008
-
Abstract
- The transcription factor IRF-4 is necessary for Th17 cell differentiation. In this issue of Immunity, Chen et al. (2008) show that IRF-4-binding protein is a critical negative regulator of IRF-4 function, regulating production of the cytokines IL-21 and IL-17.
- Subjects :
- Animals
Cell Differentiation immunology
Cytokines immunology
Cytokines metabolism
DNA-Binding Proteins immunology
DNA-Binding Proteins metabolism
Guanine Nucleotide Exchange Factors immunology
Guanine Nucleotide Exchange Factors metabolism
Interferon Regulatory Factors immunology
Interferon Regulatory Factors metabolism
Interleukin-17 metabolism
Interleukins immunology
Interleukins metabolism
Mice
Minor Histocompatibility Antigens
Nuclear Proteins immunology
Nuclear Proteins metabolism
Nuclear Receptor Subfamily 1, Group F, Member 3
Receptors, Retinoic Acid immunology
Receptors, Retinoic Acid metabolism
Receptors, Thyroid Hormone immunology
Receptors, Thyroid Hormone metabolism
STAT3 Transcription Factor immunology
STAT3 Transcription Factor metabolism
T-Lymphocytes, Helper-Inducer metabolism
Autoimmunity
Interleukin-17 immunology
T-Lymphocytes, Helper-Inducer immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4180
- Volume :
- 29
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Immunity
- Publication Type :
- Academic Journal
- Accession number :
- 19100696
- Full Text :
- https://doi.org/10.1016/j.immuni.2008.12.001