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Distribution of tenascin-C, fibronectin and collagen types III and IV during regeneration of rat submandibular gland.
- Source :
-
International journal of oral and maxillofacial surgery [Int J Oral Maxillofac Surg] 2009 Jan; Vol. 38 (1), pp. 79-84. Date of Electronic Publication: 2008 Dec 18. - Publication Year :
- 2009
-
Abstract
- The aim of this study was to determine the localization of tenascin-C, fibronectin and collagen types III and IV during regeneration of the rat submandibular gland. After 7 days' obstruction, the regenerating glands were collected at days 0, 1, 3, 5, 7, 11 and 14 after duct release to study regeneration. Immunohistochemical staining revealed that tenascin-C was strongly expressed in the epithelial cells of duct-acinar structures at days 0-3, and down-regulated in its expression from day 5 to 11, though weak expression was detected in the intercalated duct and acinar cells of the normal gland. Strong labeling of fibronectin was detected around duct-acinar structures during days 0-3 of regeneration. Type IV collagen was expressed strongly in the thickened basement membrane of acinar cells and duct-acinar structures during days 0-3, but weakly around large ducts, though type III collagen was expressed at consistent levels. These findings suggest that tenascin-C and fibronectin affect only the duct-acinar structures, and type IV but not type III collagen is involved in the regeneration of acinar cells.
- Subjects :
- Animals
Collagen Type III analysis
Collagen Type III biosynthesis
Collagen Type IV analysis
Collagen Type IV biosynthesis
Epithelial Cells chemistry
Extracellular Matrix Proteins analysis
Fibronectins biosynthesis
Immunohistochemistry
Male
Rats
Rats, Wistar
Regeneration
Salivary Ducts cytology
Salivary Ducts metabolism
Submandibular Gland cytology
Submandibular Gland metabolism
Tenascin analysis
Tenascin biosynthesis
Extracellular Matrix Proteins biosynthesis
Submandibular Gland physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0901-5027
- Volume :
- 38
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of oral and maxillofacial surgery
- Publication Type :
- Academic Journal
- Accession number :
- 19097859
- Full Text :
- https://doi.org/10.1016/j.ijom.2008.11.004