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Three-year outcome data of second-line antiretroviral therapy in Ugandan adults: good virological response but high rate of toxicity.
- Source :
-
Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) [J Int Assoc Physicians AIDS Care (Chic)] 2009 Jan-Feb; Vol. 8 (1), pp. 52-9. Date of Electronic Publication: 2008 Dec 17. - Publication Year :
- 2009
-
Abstract
- Objective: To evaluate the safety and virological response to lopinavir/ritonavir containing second-line therapy after failing a first line nonnucleoside reverse transcriptase inhibitor (NNRTI) based regimen.<br />Design: Prospective 36 months cohort study of patients switched to zidovudine/stavudine plus didanosine plus lopinavir/ritonavir capsules as second-line regimen.<br />Methodology: Structured interview, medical examination, and laboratory assessment performed every 6 months.<br />Results: We enrolled 40 patients; 1 died and 3 were lost to follow-up. Median CD4+ count at baseline was 108 cell/microL, median log viral load was 4.8 copies/mL. Sixteen (40%) patients had baseline genotypic resistant test, 14 (87%) had lamivudine resistance mutations, and all had NNRTIs resistance mutations. At month 36, 82% of the patients achieved viral suppression (<400 copies/ mL) and the median increase in CD4+ count was 214 cell/microL, (interquartile range: 128-295). Twenty-five patients (62%) experienced at least one adverse event.<br />Conclusions: Our study confirms lopinavir/ ritonavir-based second-line regimen but with a high rate of toxicities.
- Subjects :
- Adult
Anti-HIV Agents pharmacology
Anti-HIV Agents standards
Anti-Retroviral Agents pharmacology
Anti-Retroviral Agents standards
Anti-Retroviral Agents therapeutic use
CD4 Lymphocyte Count
Didanosine pharmacology
Didanosine standards
Didanosine therapeutic use
Drug Resistance, Viral
Drug Therapy, Combination
Drug-Related Side Effects and Adverse Reactions epidemiology
Female
HIV drug effects
HIV genetics
HIV Infections blood
Humans
Interviews as Topic
Lopinavir
Male
Prospective Studies
Pyrimidinones pharmacology
Pyrimidinones standards
Pyrimidinones therapeutic use
Ritonavir pharmacology
Ritonavir standards
Ritonavir therapeutic use
Stavudine pharmacology
Stavudine therapeutic use
Treatment Outcome
Uganda
Viral Load
Zidovudine pharmacology
Zidovudine standards
Zidovudine therapeutic use
Anti-HIV Agents therapeutic use
HIV Infections drug therapy
Stavudine standards
Subjects
Details
- Language :
- English
- ISSN :
- 1545-1097
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)
- Publication Type :
- Academic Journal
- Accession number :
- 19095630
- Full Text :
- https://doi.org/10.1177/1545109708328538