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[Rare neuroendocrine carcinoma of the gall bladder. Coincidental occurrence of an endometrioid ovarian adenocarcinoma].

[Rare neuroendocrine carcinoma of the gall bladder. Coincidental occurrence of an endometrioid ovarian adenocarcinoma].

Authors :
Petersen M
Meyer F
Kalinski T
Bischoff J
Bohr UR
Lippert H
Source :
Deutsche medizinische Wochenschrift (1946) [Dtsch Med Wochenschr] 2009 Jan; Vol. 134 (1-2), pp. 19-22. Date of Electronic Publication: 2008 Dec 17.
Publication Year :
2009

Abstract

History and Clinical Findings: The histological investigation of a surgical specimen (after cholecystectomy) from a 73-year-old woman revealed a poorly differentiated carcinoma with glandular structures and a lymph node metastasis.<br />Investigations: Comparative immunochemistry, done to exclude metastatic growth of the previously demonstrated endometrioid ovarian carcinoma, was (1) negative for CK7 and CA125, positive for CK20, chromogranin A and synaptophysin (gall bladder and lymph node metastasis); (2) positive for CK7 and CA125, negative for CK20, chromogranin A and synaptophysin (ovary).<br />Diagnosis: The tumor lesion within the gall bladder and lymph node was classified as a neuroendocrine carcinoma, not a metastasis of the ovarian carcinoma.<br />Treatment and Clinical Course: The patient underwent another laparotomy with resection of the stump of the cystic duct and the liver parenchyma surrounding the former gall bladder, including dissection of the lymph nodes within the hepatoduodenal ligament. After 14 months another metastasis of the neuroendocrine carcinoma of the gall bladder was found. But for eight years there has been no recurrence of the endometrioid adenocarcinoma of the left ovary.<br />Conclusion: Because of the increasing incidence of malignant diseases and second neoplasms there is a growing need for such diagnostic tests as histological and immunohistochemical analysis. This is the first case, according to the available literature, of an endometrioid adenocarcinoma of the ovary concomitant with a neuroendocrine carcinoma of the gall bladder.

Details

Language :
German
ISSN :
1439-4413
Volume :
134
Issue :
1-2
Database :
MEDLINE
Journal :
Deutsche medizinische Wochenschrift (1946)
Publication Type :
Academic Journal
Accession number :
19090447
Full Text :
https://doi.org/10.1055/s-0028-1105884