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Oral mucosal cell response to Candida albicans in transgenic mice expressing HIV-1.
- Source :
-
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2009; Vol. 470, pp. 359-68. - Publication Year :
- 2009
-
Abstract
- Controlled studies on the immunopathogenesis of mucosal candidiasis in HIV infection have been hampered by the lack of a relevant animal model. We have previously reported that oral Candida infection in CD4C/HIV transgenic mice expressing gene products of HIV-1 in immune cells and developing an AIDS-like disease closely mimics oropharyngeal candidiasis in human HIV infection. The role of defective dendritic cells and CD4+ T cells in impaired induction of protective immunity and in the phenotype of chronic oral carriage of C. albicans can now be investigated under controlled conditions in these transgenic mice.
- Subjects :
- AIDS-Related Opportunistic Infections immunology
Animals
Base Sequence
CD4-Positive T-Lymphocytes immunology
Candidiasis, Oral immunology
Cytokines genetics
Cytokines metabolism
DNA Primers genetics
Dendritic Cells immunology
Disease Models, Animal
Female
Flow Cytometry
Humans
Male
Mice
Mice, Transgenic
AIDS-Related Opportunistic Infections etiology
Candida albicans immunology
Candida albicans pathogenicity
Candidiasis, Oral etiology
HIV-1 genetics
HIV-1 pathogenicity
Mouth Mucosa immunology
Mouth Mucosa microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1064-3745
- Volume :
- 470
- Database :
- MEDLINE
- Journal :
- Methods in molecular biology (Clifton, N.J.)
- Publication Type :
- Academic Journal
- Accession number :
- 19089395
- Full Text :
- https://doi.org/10.1007/978-1-59745-204-5_25