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Predictive Role of p53 Protein as a Single Marker or Associated to Ki67 Antigen in Oral Carcinogenesis.
- Source :
-
The open dentistry journal [Open Dent J] 2008; Vol. 2, pp. 24-9. Date of Electronic Publication: 2008 Feb 21. - Publication Year :
- 2008
-
Abstract
- p53 over-expression has been proposed as a reliable marker associated to oral carcinogenesis, although only about 50% of oral carcinomas (OSCC) are associated with p53 over-expression and even p53-negative lesions can progress to OSCC. The aim of the study was to determine whether the combination of p53 over-expression and p53 low-expression associated with Ki67 over-expression (high Ki67/p53 ratio) could lead to a more sensitive parameter. Immunohistochemical expression of Ki67 and p53 was measured in 54 specimens from OSCC; 27 specimens from moderate/severe epithelial dysplasia; 32 specimens from oral leukoplakias without epithelial dysplasia, and 13 specimens with normal epithelium. p53 over-expression was found in 31 (53%) samples from OSCC, in 10 (37%) samples from severe dysplasias, and in 5 (15%) samples from non-dysplastic lesions, while the combination of high p53 values with high Ki67/p53 ratio was observed in 93% of OSCC, in 81% of dysplastic lesions, and in 50% of non-dysplastic lesions. This parameter may have a clinical implication to detect early lesions with an impairment of p53 pathway, and probably at risk of progress to OSCC.
Details
- Language :
- English
- ISSN :
- 1874-2106
- Volume :
- 2
- Database :
- MEDLINE
- Journal :
- The open dentistry journal
- Publication Type :
- Academic Journal
- Accession number :
- 19088879
- Full Text :
- https://doi.org/10.2174/1874210600802010024