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Functional evidence that the Ser-195 residue of staphylococcal exfoliative toxin A is essential for biological activity.
- Source :
-
Infection and immunity [Infect Immun] 1991 Sep; Vol. 59 (9), pp. 3337-9. - Publication Year :
- 1991
-
Abstract
- The substitution of the serine 195 residue of staphylococcal exfoliative toxin A by a cysteine residue led to a biologically inactive protein. This result is consistent with the hypothesis that exfoliative toxin A could be a protease or a lipase. However, no protease or lipase activity was detected with the native toxin.
- Subjects :
- Amino Acid Sequence
Animals
Base Sequence
DNA, Bacterial genetics
Escherichia coli genetics
Exfoliatins genetics
Gene Expression
Mice
Molecular Sequence Data
Mutagenesis, Site-Directed
Rabbits
Recombinant Proteins biosynthesis
Staphylococcal Scalded Skin Syndrome metabolism
Structure-Activity Relationship
Exfoliatins chemistry
Serine chemistry
Staphylococcus aureus genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0019-9567
- Volume :
- 59
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Infection and immunity
- Publication Type :
- Academic Journal
- Accession number :
- 1908832
- Full Text :
- https://doi.org/10.1128/iai.59.9.3337-3339.1991