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Increased risk of zoonotic Salmonella and Campylobacter gastroenteritis in patients with haematological malignancies: a population-based study.
- Source :
-
Annals of hematology [Ann Hematol] 2009 Aug; Vol. 88 (8), pp. 761-7. Date of Electronic Publication: 2008 Dec 16. - Publication Year :
- 2009
-
Abstract
- We hypothesised that haematological malignancies increase the risk of acquiring zoonotic Salmonella or Campylobacter gastroenteritis. The population-based study comprised all first-time Salmonella/Campylobacter gastroenteritis cases in two Danish counties (1991-2003), with age- and gender-matched controls from the background population. We linked the study cohort to registries to obtain data on malignancies, chemotherapy (yes/no), and main comorbidities diagnosed before Salmonella/Campylobacter gastroenteritis. Based on this design, we determined incidence rate ratios (IRR) in conditional logistic regression analyses, and we used weighted mean regression curves to evaluate fluctuations in risk 0-5 years after the malignancy diagnosis. Sixty-eight of 13,324 cases (0.5%) and 29 of 26,648 controls (0.1%) had haematological malignancy before their Salmonella/Campylobacter gastroenteritis. Comorbidity-adjusted IRR for Salmonella/Campylobacter gastroenteritis in patients with haematological malignancy as compared to patients without malignancy were 4.46 [95% confidence intervals (CI), 2.88-6.90] for all individuals, 8.33 (95% CI, 4.31-16.1) for Salmonella, and 2.17 (95% CI, 1.15-4.08) for Campylobacter. Stratification on chemotherapy treatment did not change these estimates. In time-related analyses, IRR were 7-8 in the first 2 years after the haematological malignancy diagnosis and 4-5 in the following 3 years. Patients with haematological malignancy had increased long-term risk of enquiring Salmonella or Campylobacter gastroenteritis.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Animals
Antineoplastic Agents pharmacology
Campylobacter Infections epidemiology
Case-Control Studies
Child
Child, Preschool
Denmark epidemiology
Disease Susceptibility
Female
Gastroenteritis epidemiology
Gastroenteritis microbiology
Hematologic Neoplasms epidemiology
Humans
Incidence
Infant
Infant, Newborn
Male
Middle Aged
Opportunistic Infections
Registries
Regression, Psychology
Risk
Salmonella Infections epidemiology
Young Adult
Zoonoses
Campylobacter Infections etiology
Gastroenteritis etiology
Hematologic Neoplasms complications
Salmonella Infections etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0584
- Volume :
- 88
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Annals of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 19083236
- Full Text :
- https://doi.org/10.1007/s00277-008-0662-x