Back to Search Start Over

Role of thyrotropin-releasing hormone in acid secretory response induced by lowering of body temperature in the rat.

Role of thyrotropin-releasing hormone in acid secretory response induced by lowering of body temperature in the rat.

Authors :
Niida H
Takeuchi K
Okabe S
Source :
European journal of pharmacology [Eur J Pharmacol] 1991 Jun 06; Vol. 198 (2-3), pp. 137-42.
Publication Year :
1991

Abstract

Acid secretory and mucosal ulcerogenic responses to hypothermia (36-24 degrees C) were examined in anesthetized rats, and the role of thyrotropin-releasing hormone (TRH) in these responses was investigated. Lowering of body temperature (less than 32 degrees C) induced acid hypersecretion and damage in the gastric mucosa. These responses reached a maximum at a body temperature of 28 degrees C and were completely abolished by bilateral cervical vagotomy and significantly inhibited by intracerebroventricular (i.c.v.) administration of TRH antiserum (10 microliters/rat). TRH (10 micrograms/rat) given i.c.v. to the normothermia rat, caused an increase of acid secretion with a pattern similar to those observed during hypothermia. The blood levels of thyroid-stimulating hormone rose significantly during exposure of cold, and this response preceded the onset of acid hypersecretion and lesion formation. Thus, lowering of body temperature induces vagal-dependent gastric acid secretion, probably mediated by TRH released in response to cold exposure, and may be an important element in the etiology of stress ulceration.

Details

Language :
English
ISSN :
0014-2999
Volume :
198
Issue :
2-3
Database :
MEDLINE
Journal :
European journal of pharmacology
Publication Type :
Academic Journal
Accession number :
1907561
Full Text :
https://doi.org/10.1016/0014-2999(91)90612-t