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Role of thyrotropin-releasing hormone in acid secretory response induced by lowering of body temperature in the rat.
Role of thyrotropin-releasing hormone in acid secretory response induced by lowering of body temperature in the rat.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 1991 Jun 06; Vol. 198 (2-3), pp. 137-42. - Publication Year :
- 1991
-
Abstract
- Acid secretory and mucosal ulcerogenic responses to hypothermia (36-24 degrees C) were examined in anesthetized rats, and the role of thyrotropin-releasing hormone (TRH) in these responses was investigated. Lowering of body temperature (less than 32 degrees C) induced acid hypersecretion and damage in the gastric mucosa. These responses reached a maximum at a body temperature of 28 degrees C and were completely abolished by bilateral cervical vagotomy and significantly inhibited by intracerebroventricular (i.c.v.) administration of TRH antiserum (10 microliters/rat). TRH (10 micrograms/rat) given i.c.v. to the normothermia rat, caused an increase of acid secretion with a pattern similar to those observed during hypothermia. The blood levels of thyroid-stimulating hormone rose significantly during exposure of cold, and this response preceded the onset of acid hypersecretion and lesion formation. Thus, lowering of body temperature induces vagal-dependent gastric acid secretion, probably mediated by TRH released in response to cold exposure, and may be an important element in the etiology of stress ulceration.
- Subjects :
- Animals
Body Temperature drug effects
Cold Temperature
Gastric Mucosa metabolism
Gastric Mucosa pathology
Male
Radioimmunoassay
Rats
Rats, Inbred Strains
Thyrotropin blood
Thyrotropin-Releasing Hormone immunology
Vagotomy, Proximal Gastric
Body Temperature physiology
Gastric Acid metabolism
Hypothermia
Thyrotropin-Releasing Hormone physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 198
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 1907561
- Full Text :
- https://doi.org/10.1016/0014-2999(91)90612-t