Back to Search Start Over

Mobilization of qnrB2 and ISCR1 in plasmids.

Authors :
Chen YT
Liao TL
Liu YM
Lauderdale TL
Yan JJ
Tsai SF
Source :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2009 Mar; Vol. 53 (3), pp. 1235-7. Date of Electronic Publication: 2008 Dec 15.
Publication Year :
2009

Abstract

The DNA sequences of two IncHI2 plasmids, pEC-IMP and pEC-IMPQ, from metallo-beta-lactamase-producing Enterobacter cloacae clinical isolates were determined. The two conjugative plasmids are almost identical, but pEC-IMPQ carries an additional segment containing an orf513 (ISCR1), a truncated 3' conserved sequence, and a qnrB2. Comparative analyses provide support for the proposed ISCR1-mediated gene mobilization.

Subjects

Subjects :
Base Sequence
Conjugation, Genetic
Enterobacter cloacae enzymology
Enterobacter cloacae genetics
Enterobacter cloacae isolation & purification
Enterobacteriaceae Infections
Humans
Molecular Sequence Data
Open Reading Frames
Sequence Analysis, DNA
beta-Lactamases biosynthesis
Anti-Bacterial Agents pharmacology
Drug Resistance, Bacterial genetics
Genes, Bacterial
Plasmids
Quinolones pharmacology

Details

Language :
English
ISSN :
1098-6596
Volume :
53
Issue :
3
Database :
MEDLINE
Journal :
Antimicrobial agents and chemotherapy
Publication Type :
Academic Journal
Accession number :
19075060
Full Text :
https://doi.org/10.1128/AAC.00970-08
Full Text Access
View/download PDF

Tools

Authors Abstract Subjects Details