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Study on DNA damage induced by CdSe quantum dots using nucleic acid molecular "light switches" as probe.

Study on DNA damage induced by CdSe quantum dots using nucleic acid molecular "light switches" as probe.

Authors :
Liang J
He Z
Zhang S
Huang S
Ai X
Yang H
Han H
Source :
Talanta [Talanta] 2007 Mar 15; Vol. 71 (4), pp. 1675-8. Date of Electronic Publication: 2006 Sep 01.
Publication Year :
2007

Abstract

The calf thymus DNA (ctDNA) damage induced by water-soluble CdSe quantum dots (QDs) was investigated using nucleic acid molecular "light switches" as probe. It was found that little ctDNA was damaged by CdSe QDs without UV irradiation. However, under UV irradiation, ctDNA was nicked by CdSe QDs very clearly. The mechanism of ctDNA damage was also discussed. The results strongly suggested that the ctDNA damage caused by CdSe QDs was not due to photo-induced liberation of Cd(2+), but due to the production of free radicals and reactive oxygen species.

Details

Language :
English
ISSN :
1873-3573
Volume :
71
Issue :
4
Database :
MEDLINE
Journal :
Talanta
Publication Type :
Academic Journal
Accession number :
19071507
Full Text :
https://doi.org/10.1016/j.talanta.2006.07.048