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Randomised trial of epirubicin alone versus 5-fluorouracil, epirubicin and mitomycin C in locally advanced and metastatic carcinoma of the pancreas.
- Source :
-
British journal of cancer [Br J Cancer] 1991 Jul; Vol. 64 (1), pp. 179-81. - Publication Year :
- 1991
-
Abstract
- Sixty-nine unselected patients with locally advanced and metastatic carcinoma of the pancreas, who had not received previous chemotherapy or radiotherapy were randomised to receive either 5-fluorouracil, epirubicin and mitomycin C (FEM) or epirubicin. Survival was not significantly different in the two arms. Toxic reactions (WHO grade greater than 3) in the FEM and epirubicin arm respectively included nausea (2), (4), severe alopecia (1) (3) and leucopenia (1), (5), none of these were statistically significant. We therefore suggest that combination chemotherapy should not be used in preference to single agent chemotherapy as standard treatment for locally advanced or metastatic cancer of the pancreas.
- Subjects :
- Antineoplastic Agents administration & dosage
Antineoplastic Combined Chemotherapy Protocols adverse effects
Epirubicin administration & dosage
Epirubicin adverse effects
Fluorouracil administration & dosage
Follow-Up Studies
Humans
Mitomycin
Mitomycins administration & dosage
Neoplasm Metastasis
Pancreatic Neoplasms diagnosis
Pancreatic Neoplasms pathology
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Epirubicin therapeutic use
Pancreatic Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0007-0920
- Volume :
- 64
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- British journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 1906726
- Full Text :
- https://doi.org/10.1038/bjc.1991.265