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Total saponins of Panax notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion.
- Source :
-
Journal of ethnopharmacology [J Ethnopharmacol] 2009 Jan 30; Vol. 121 (3), pp. 412-8. Date of Electronic Publication: 2008 Nov 18. - Publication Year :
- 2009
-
Abstract
- Ethnopharmacological Relevance: Total saponins of Panax notoginseng (TSPN), main constituents extracted from Panax Notoginseng, a highly valued traditional Chinese medicine, have been shown to be an effective agent on cerebral infarction.<br />Aim of the Study: The effects of TSPN on apoptosis and expressions of caspase-1, caspase-3 and caspase-8 were studied after cerebral ischemia for 2 h followed by reperfusion for 46 h in rats.<br />Materials and Methods: Rats were subjected to transient middle cerebral artery occlusion (MCAO) model using the intraluminal thread. TSPN was administered intraperitoneally at 5 min before and 12 h, 24 h and 36 h after MCAO, respectively.<br />Results: TSPN (at the dose of 25 mg/kg) significantly attenuated TUNEL-positive cells and reduced the expression of caspase-1 and caspase-3 compared to the model group, while it had no obvious effect on the expression of caspase-8.<br />Conclusions: The neuroprotective effect of TSPN on focal ischemia may be related to inhibition of apoptosis and caspases activation.
- Subjects :
- Animals
Brain drug effects
Female
Infarction, Middle Cerebral Artery drug therapy
Male
Nimodipine therapeutic use
Phytotherapy
Plant Extracts pharmacology
Plant Extracts therapeutic use
Random Allocation
Rats
Rats, Sprague-Dawley
Saponins pharmacology
Vasodilator Agents therapeutic use
Apoptosis drug effects
Brain Ischemia drug therapy
Caspase Inhibitors
Panax notoginseng
Reperfusion Injury drug therapy
Saponins therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7573
- Volume :
- 121
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 19059471
- Full Text :
- https://doi.org/10.1016/j.jep.2008.10.042