Back to Search
Start Over
Copper/silver-cocatalyzed Conia-ene reactions of 2-alkynic 1,3-dicarbonyl compounds.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2009 Jan 02; Vol. 74 (1), pp. 412-4. - Publication Year :
- 2009
-
Abstract
- A copper/silver-catalyzed Conia-ene reaction has been developed for selectively constructing five-membered and six-membered rings. In the presence of (CuOTf)(2) x C(6)H(6) and AgBF(4), a variety of 2-alkynic 1,3-dicarbonyl compounds underwent the Conia-ene intramolecular reaction smoothly in moderate to good yields. It is noteworthy that both 2-phenylacetylhept-6-ynenitrile and diethyl 2-(pent-4-ynyl)malonate are also suitable substrates under the standard conditions, and the selectivity toward endo- or exo-products depends on the substituents at the terminal of alkynes.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 74
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 19053618
- Full Text :
- https://doi.org/10.1021/jo802133w