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A new cytotoxic pregnanone from Calotropis gigantea.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2008 Dec 04; Vol. 13 (12), pp. 3033-9. Date of Electronic Publication: 2008 Dec 04. - Publication Year :
- 2008
-
Abstract
- A new pregnanone, named calotropone (1), was isolated from the EtOH extract of the roots of Calotropis gigantea L. together with a known cardiac glycoside. The structures were elucidated by a study of their physical and spectral data. Compounds 1 and 2 displayed inhibitory effects towards chronic myelogenous leukemia K562 and human gastric cancer SGC-7901 cell lines.
- Subjects :
- Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic isolation & purification
Antineoplastic Agents, Phytogenic pharmacology
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
Pregnanolone chemistry
Pregnanolone isolation & purification
Pregnanolone pharmacology
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Calotropis chemistry
Pregnanolone analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 13
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 19052526
- Full Text :
- https://doi.org/10.3390/molecules13123033