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Preclinical toxicological assessment of a phytotherapeutic product--CPV (based on dry extracts of Crataegus oxyacantha L., Passiflora incarnata L., and Valeriana officinalis L.).
- Source :
-
Phytotherapy research : PTR [Phytother Res] 2009 Jan; Vol. 23 (1), pp. 33-40. - Publication Year :
- 2009
-
Abstract
- Associations of plants have been widely used, for centuries, in Ayurveda and in Chinese medicine and have been increasingly acknowledged in Western medicine. The objective of this study is to assess the level of toxicity of an association of three plants: Crataegus oxyacantha, Passiflora incarnata, and Valeriana officinalis (CPV extract). This association was administered to rats, mice, and dogs, both acute and chronically for 180 days. The tests used in the acute experiments were: observational pharmacological screening, LD(50), motor coordination and motor activity. Chronic tests carried out were: weight gain/loss and behavioral parameters in rats and in mice; estrus cycle, effects on fertility, and teratogenic studies in rats and of mutagenic features in mice, in addition to the Ames test. The following parameters were assessed in dogs: weight gain/loss, general physical conditions, water/food consumption and anatomopathological examination of the organs subsequent to the 180 days of treatment. All of the results were negative, showing that CPV administered in high doses and over a long period of time presents no toxicity, suggestive of the fact that this is an association devoid of risk for human beings.<br /> (Copyright 2008 John Wiley & Sons, Ltd.)
- Subjects :
- Animals
Dogs
Dose-Response Relationship, Drug
Estrus drug effects
Female
Fertility drug effects
Lethal Dose 50
Male
Mice
Motor Activity drug effects
Mutagenicity Tests
Rats
Rats, Wistar
Toxicity Tests, Acute
Toxicity Tests, Chronic
Weight Gain drug effects
Weight Loss drug effects
Crataegus toxicity
Passiflora toxicity
Plant Extracts toxicity
Valerian toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1099-1573
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Phytotherapy research : PTR
- Publication Type :
- Academic Journal
- Accession number :
- 19048610
- Full Text :
- https://doi.org/10.1002/ptr.2499