Back to Search
Start Over
Long-term efficacy and safety of chronic globus pallidus internus stimulation in different types of primary dystonia.
- Source :
-
Stereotactic and functional neurosurgery [Stereotact Funct Neurosurg] 2009; Vol. 87 (1), pp. 8-17. Date of Electronic Publication: 2008 Nov 27. - Publication Year :
- 2009
-
Abstract
- Background: Deep brain stimulation (DBS) of the globus pallidus internus (GPi) offers a very promising therapy for medically intractable dystonia. However, little is known about the long-term benefit and safety of this procedure. We therefore performed a retrospective long-term analysis of 18 patients (age 12-78 years) suffering from primary generalized (9), segmental (6) or focal (3) dystonia (minimum follow-up: 36 months).<br />Methods: Outcome was assessed using the Burke-Fahn-Marsden (BFM) scores (generalized dystonia) and the Tsui score (focal/segmental dystonia). Follow-up ranged between 37 and 90 months (mean 60 months).<br />Results: Patients with generalized dystonia showed a mean improvement in the BFM movement score of 39.4% (range 0-68.8%), 42.5% (range -16.0 to 81.3%) and 46.8% (range -2.7 to 83.1%) at the 3- and 12-month, and long-term follow-up, respectively. In focal/segmental dystonia, the mean reduction in the Tsui score was 36.8% (range 0-100%), 65.1% (range 16.7-100%) and 59.8% (range 16.7-100%) at the 3- and 12-month, and long-term follow-up, respectively. Local infections were noted in 2 patients and hardware problems (electrode dislocation and breakage of the extension cable) in 1 patient.<br />Conclusion: Our data showed Gpi-DBS to offer a very effective and safe therapy for different kinds of primary dystonia, with a significant long-term benefit in the majority of cases.
- Subjects :
- Adolescent
Adult
Aged
Child
Deep Brain Stimulation adverse effects
Disability Evaluation
Dystonic Disorders physiopathology
Electrodes
Female
Follow-Up Studies
Humans
Male
Middle Aged
Retrospective Studies
Severity of Illness Index
Stereotaxic Techniques adverse effects
Treatment Outcome
Young Adult
Deep Brain Stimulation methods
Dystonic Disorders therapy
Globus Pallidus physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0372
- Volume :
- 87
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Stereotactic and functional neurosurgery
- Publication Type :
- Academic Journal
- Accession number :
- 19039258
- Full Text :
- https://doi.org/10.1159/000177623