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Ferroquine, an ingenious antimalarial drug: thoughts on the mechanism of action.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2008 Nov 20; Vol. 13 (11), pp. 2900-7. Date of Electronic Publication: 2008 Nov 20. - Publication Year :
- 2008
-
Abstract
- Ferroquine (FQ or SR97193) is a novel antimalarial drug candidate, currently in development at Sanofi-Aventis. In contrast to conventional drugs, FQ is the first organometallic drug: a ferrocenyl group covalently flanked by a 4-aminoquinoline and a basic alkylamine. FQ is able to overcome the CQ resistance problem, an important limit to the control of Plasmodium falciparum, the principal causative agent of malaria. After fifteen years of effort, it is now possible to propose a multifactorial mechanism of action of FQ by its capacity to target lipids, to inhibit the formation of hemozoin and to generate reactive oxygen species.
- Subjects :
- Aminoquinolines chemistry
Animals
Antimalarials chemistry
Antimalarials pharmacology
Drug Resistance
Ferrous Compounds chemistry
Hemin antagonists & inhibitors
Lipids chemistry
Metallocenes
Reactive Oxygen Species chemical synthesis
Aminoquinolines pharmacology
Ferrous Compounds pharmacology
Plasmodium falciparum drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 13
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 19020475
- Full Text :
- https://doi.org/10.3390/molecules13112900