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Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia.

Authors :
Buijtels PC
van de Sande WW
Parkinson S
Petit PL
van der Sande MA
van Soolingen D
Verbrugh HA
van Belkum A
Source :
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2008 Dec; Vol. 12 (12), pp. 1485-8.
Publication Year :
2008

Abstract

Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the -2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3-5.5).

Details

Language :
English
ISSN :
1027-3719
Volume :
12
Issue :
12
Database :
MEDLINE
Journal :
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Publication Type :
Academic Journal
Accession number :
19017462