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Low radiation dose imaging of myocardial perfusion and coronary angiography with a hybrid PET/CT scanner.
- Source :
-
Clinical physiology and functional imaging [Clin Physiol Funct Imaging] 2009 Jan; Vol. 29 (1), pp. 81-8. Date of Electronic Publication: 2008 Nov 06. - Publication Year :
- 2009
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Abstract
- Objectives: To test the image quality and feasibility of a sequential low radiation dose protocol for hybrid cardiac PET/CT angiography (CTA).<br />Background: Multidetector computed tomography (MDCT) is a non-invasive method for coronary angiography. The negative predictive value of MDCT is high but perfusion imaging has a role in detecting functional significance of coronary lesions. This has encouraged combining these techniques. However, radiation dose is of concern. We report our first experiences with a low dose sequential CTA mode applicable to hybrid imaging.<br />Methods: In the first phase, 10 consecutive cardiac MDCT angiographies were performed with spiral acquisition and compared in terms of image quality and dose with the following 10 patients performed with a new sequential mode. In the second phase, feasibility and radiation dose of a combined (15)O-water rest-stress PET perfusion/sequential CTA protocol were assessed in another group of 61 consecutive patients.<br />Results: Mean effective radiation dose was 60% lower in the sequential group than in the spiral group (19.3 versus 7.6 mSv, P<0.001). In the second phase, the new sequential hybrid protocol proved possible in 87% of the patients given the preconditions determined by the manufacturer. Mean effective dose of the CT acquisition was 7.6 mSv and total dose from the PET/CTA hybrid study 9.5 mSv.<br />Conclusion: Low dose PET/CT allows cardiac hybrid studies with <10 mSv. The protocol can be applied to almost nine out of 10 patients with CT image quality comparable to spiral acquisition.
- Subjects :
- Aged
Coronary Artery Disease diagnostic imaging
Equipment Design
Feasibility Studies
Female
Humans
Male
Middle Aged
Oxygen Radioisotopes
Predictive Value of Tests
Prospective Studies
Radiographic Image Interpretation, Computer-Assisted
Tomography, Spiral Computed instrumentation
Coronary Angiography instrumentation
Coronary Artery Disease diagnosis
Myocardial Perfusion Imaging instrumentation
Positron-Emission Tomography instrumentation
Radiation Dosage
Tomography, X-Ray Computed instrumentation
Subjects
Details
- Language :
- English
- ISSN :
- 1475-097X
- Volume :
- 29
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical physiology and functional imaging
- Publication Type :
- Academic Journal
- Accession number :
- 19016814
- Full Text :
- https://doi.org/10.1111/j.1475-097X.2008.00838.x