Back to Search
Start Over
Postoperative irradiation of left-sided breast cancer patients and cardiac toxicity. Does deep inspiration breath-hold (DIBH) technique protect the heart?
- Source :
-
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] [Strahlenther Onkol] 2008 Jul; Vol. 184 (7), pp. 354-8. Date of Electronic Publication: 2008 Oct 01. - Publication Year :
- 2008
-
Abstract
- Purpose: To evaluate the impact of deep inspiration breath-hold (DIBH) technique during postoperative left-sided tangential breast irradiation on minimizing irradiated heart amount compared to normal breathing.<br />Patients and Methods: In 22 patients with left-sided breast cancer, postoperative CT scanning was performed in different respiratory phases using the Varian Real-time Position Management System for monitoring of respiratory chest wall motion. Each patient underwent two CT scans: during normal breathing and DIBH. For each scan, an optimized plan was designed with tangential photon fields encompassing the clinical target volume after breast-conserving surgery or modified radical mastectomy. The resulting dose-volume histograms were compared between both breathing techniques for irradiated volume and dose to the heart.<br />Results: The mean patient age was 51 years (range: 34-77 years). The DIBH-gated technique was well accepted by all patients. The significant reduction in dose to the irradiated heart volume for the DIBH technique compared to the normal breathing was 56% (mean heart dose: 2.3 Gy vs. 1.3 Gy; p = 0.01).<br />Conclusion: This study demonstrates that irradiated cardiac volumes can significantly be reduced in left-sided breast cancer patients using DIBH technique for postoperative tangential radiotherapy. Moreover, the technique is safe and feasible in daily routine.
- Subjects :
- Adult
Aged
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Breast Neoplasms diagnostic imaging
Breast Neoplasms drug therapy
Breast Neoplasms surgery
Chemotherapy, Adjuvant
Female
Humans
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Middle Aged
Radiotherapy
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Adjuvant
Tomography, X-Ray Computed
Breast Neoplasms radiotherapy
Heart radiation effects
Inhalation
Mastectomy, Modified Radical
Mastectomy, Segmental
Radiation Injuries prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0179-7158
- Volume :
- 184
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
- Publication Type :
- Academic Journal
- Accession number :
- 19016033
- Full Text :
- https://doi.org/10.1007/s00066-008-1852-0