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Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis.
- Source :
-
Arthritis research & therapy [Arthritis Res Ther] 2008; Vol. 10 (6), pp. R134. Date of Electronic Publication: 2008 Nov 14. - Publication Year :
- 2008
-
Abstract
- Introduction: Cartilage oligomeric matrix protein (COMP) is a homopentameric protein in cartilage. The development of arthritis, like collagen-induced arthritis (CIA), involves cartilage as a target tissue. We have investigated the development of CIA in COMP-deficient mice.<br />Methods: COMP-deficient mice in the 129/Sv background were backcrossed for 10 generations against B10.Q mice, which are susceptible to chronic CIA. COMP-deficient and wild-type mice were tested for onset, incidence, and severity of arthritis in both the collagen and collagen antibody-induced arthritis models. Serum anti-collagen II and anti-COMP antibodies as well as serum COMP levels in arthritic and wild-type mice were measured by enzyme-linked immunosorbent assay.<br />Results: COMP-deficient mice showed a significant early onset and increase in the severity of CIA in the chronic phase, whereas collagen II-antibody titers were similar in COMP-deficient and wild-type controls. COMP antibodies were not found in wild-type mice. Finally, COMP-deficient and wild-type mice responded similarly to collagen antibody-induced arthritis, indicating no difference in how collagen II antibodies interact with COMP-deficient cartilage during the initial stages of arthritis.<br />Conclusions: COMP deficiency enhances the early onset and development of chronic arthritis but does not affect collagen II autoimmunity. These findings accentuate the importance of COMP in cartilage stability.
- Subjects :
- Age of Onset
Animals
Arthritis, Experimental genetics
Arthritis, Experimental metabolism
Cartilage, Articular immunology
Cartilage, Articular pathology
Chronic Disease
Collagen Type II immunology
Extracellular Matrix Proteins genetics
Extracellular Matrix Proteins immunology
Female
Glycoproteins genetics
Glycoproteins immunology
Inflammation Mediators immunology
Inflammation Mediators metabolism
Male
Matrilin Proteins
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Knockout
Rats
Severity of Illness Index
Arthritis, Experimental immunology
Extracellular Matrix Proteins deficiency
Glycoproteins deficiency
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6362
- Volume :
- 10
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Arthritis research & therapy
- Publication Type :
- Academic Journal
- Accession number :
- 19014566
- Full Text :
- https://doi.org/10.1186/ar2551