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Long-term efficacy and safety of tolterodine in children with neurogenic detrusor overactivity.
- Source :
-
Journal of pediatric urology [J Pediatr Urol] 2008 Dec; Vol. 4 (6), pp. 428-33. Date of Electronic Publication: 2008 Jul 02. - Publication Year :
- 2008
-
Abstract
- Objective: We evaluated long-term (> or =12 months) efficacy and safety of tolterodine in children with neurogenic detrusor overactivity.<br />Subjects and Methods: Subjects successfully completed one of three 12-week, open-label studies and had stable neurologic disease and urodynamic evidence of neurogenic detrusor overactivity requiring intermittent catheterization. Drug formulation and dosing were based on age (4 months-4 years, tolterodine oral solution 0.2-2mg twice daily; 5-10 years, tolterodine oral solution 0.5-4 mg twice daily; 11-16 years, tolterodine extended-release capsules 2, 4, or 6 mg once daily). Daily doses were individualized for each subject. Efficacy was evaluated urodynamically and using parent-completed 3-day bladder diaries.<br />Results: Thirty subjects were enrolled. Functional bladder capacity (volume at first leakage, first sensation of bladder fullness or 40 cm H(2)O pressure) increased by month 12 in the younger age groups but not in the oldest subjects. Volume to first detrusor contraction >10 cm H(2)O pressure and detrusor leak point pressure did not change in any age group. The number of incontinence episodes per 24h decreased in all subjects, as did the number of catheterizations per 24h. Mean volume per catheterization increased in all subjects. Seven treatment-related adverse events were reported.<br />Conclusions: Both tolterodine formulations were effective and well tolerated in children with neurogenic detrusor overactivity.
- Subjects :
- Adolescent
Benzhydryl Compounds adverse effects
Child
Child, Preschool
Cresols adverse effects
Female
Humans
Infant
Male
Muscarinic Antagonists adverse effects
Muscle Hypertonia physiopathology
Patient Satisfaction
Phenylpropanolamine adverse effects
Tolterodine Tartrate
Treatment Outcome
Urinary Bladder drug effects
Urinary Bladder physiology
Urodynamics
Benzhydryl Compounds administration & dosage
Cresols administration & dosage
Muscarinic Antagonists administration & dosage
Muscle Hypertonia drug therapy
Phenylpropanolamine administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4898
- Volume :
- 4
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of pediatric urology
- Publication Type :
- Academic Journal
- Accession number :
- 19013412
- Full Text :
- https://doi.org/10.1016/j.jpurol.2008.05.003