How to very efficiently functionalize gold nanoparticles by "click" chemistry.

Authors :: Boisselier E
Salmon L
Ruiz J
Astruc D
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2008 Nov 30 (44), pp. 5788-90. Date of Electronic Publication: 2008 Oct 01.
Publication Year :: 2008
Abstract: Difficulties previously encountered in the very useful "click" functionalization of gold nanoparticles (AuNPs) resulting in low yields are now overcome by using specific conditions: 1:1 water-THF medium, stoichiometric CuSO(4) and sodium ascorbate, inert atmosphere at 20 degrees C that provide quantitative "click" reactions between azidoalkylthiolate-AuNPs with various hydrophilic (PEG-containing) and hydrophobic (organic and organometallic) alkynes.