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Resolving discogenic pain.
- Source :
-
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society [Eur Spine J] 2008 Dec; Vol. 17 Suppl 4, pp. 428-31. Date of Electronic Publication: 2008 Nov 13. - Publication Year :
- 2008
-
Abstract
- Recent basic science studies on discogenic low back pain have provided new knowledge about this condition. This paper reviews some of these results and presents an overview of the following findings. The rat lumbar intervertebral disk may be innervated non-segmentally through the paravertebral sympathetic nerve and segmentally through the sinuvertebral nerves, and also by dichotomizing sensory fibers. The exposure of the nucleus pulposus (NP) to the outer annulus fibrosus (AF) may induce nerve injury and ingrowth into the disk. Nerve growth factor (NGF)-sensitive neurons are predominant in the rat intervertebral disk, which indicates that hyperalgesic responses can be induced by inflammation. NGF in the NP may promote axonal growth. Lumbar fusion may inhibit nerve ingrowth into the degenerated disk and reduce the percentage of calcitonin gene related peptide (CGRP)-positive neurons.
- Subjects :
- Animals
Back Pain etiology
Back Pain metabolism
Calcitonin Gene-Related Peptide metabolism
Fibrocartilage innervation
Fibrocartilage metabolism
Fibrocartilage physiopathology
Humans
Inflammation metabolism
Inflammation physiopathology
Intervertebral Disc metabolism
Intervertebral Disc Displacement complications
Intervertebral Disc Displacement metabolism
Nerve Growth Factor metabolism
Nociceptors cytology
Nociceptors metabolism
Rats
Sensory Receptor Cells cytology
Sensory Receptor Cells physiology
Sympathetic Fibers, Postganglionic anatomy & histology
Sympathetic Fibers, Postganglionic physiology
Back Pain physiopathology
Intervertebral Disc innervation
Intervertebral Disc physiopathology
Intervertebral Disc Displacement physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0932
- Volume :
- 17 Suppl 4
- Database :
- MEDLINE
- Journal :
- European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
- Publication Type :
- Academic Journal
- Accession number :
- 19005695
- Full Text :
- https://doi.org/10.1007/s00586-008-0752-4