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FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians.
- Source :
-
Diabetologia [Diabetologia] 2009 Feb; Vol. 52 (2), pp. 247-52. Date of Electronic Publication: 2008 Nov 13. - Publication Year :
- 2009
-
Abstract
- Aims and Hypothesis: Variants of the FTO (fat mass and obesity associated) gene are associated with obesity and type 2 diabetes in white Europeans, but these associations are not consistent in Asians. A recent study in Asian Indian Sikhs showed an association with type 2 diabetes that did not seem to be mediated through BMI. We studied the association of FTO variants with type 2 diabetes and measures of obesity in South Asian Indians in Pune.<br />Methods: We genotyped, by sequencing, two single nucleotide polymorphisms, rs9939609 and rs7191344, in the FTO gene in 1,453 type 2 diabetes patients and 1,361 controls from Pune, Western India and a further 961 population-based individuals from Mysore, South India.<br />Results: We observed a strong association of the minor allele A at rs9939609 with type 2 diabetes (OR per allele 1.26; 95% CI 1.13-1.40; p = 3 x 10(-5)). The variant was also associated with BMI but this association appeared to be weaker (0.06 SDs; 95% CI 0.01-0.10) than the previously reported effect in Europeans (0.10 SDs; 95% CI 0.09-0.12; heterogeneity p = 0.06). Unlike in the Europeans, the association with type 2 diabetes remained significant after adjusting for BMI (OR per allele for type 2 diabetes 1.21; 95% CI 1.06-1.37; p = 4.0 x 10(-3)), and also for waist circumference and other anthropometric variables.<br />Conclusions: Our study replicates the strong association of FTO variants with type 2 diabetes and similar to the study in North Indians Sikhs, shows that this association may not be entirely mediated through BMI. This could imply underlying differences between Indians and Europeans in the mechanisms linking body size with type 2 diabetes.
- Subjects :
- Adult
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Asian People statistics & numerical data
Blood Pressure
Body Mass Index
Case-Control Studies
DNA Replication genetics
Diabetes Mellitus, Type 2 epidemiology
Ethnicity statistics & numerical data
Europe epidemiology
Female
Genotype
Humans
India epidemiology
Male
Middle Aged
Regression Analysis
Waist Circumference
White People statistics & numerical data
Diabetes Mellitus, Type 2 genetics
Genetic Variation
Polymorphism, Single Nucleotide
Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0428
- Volume :
- 52
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Diabetologia
- Publication Type :
- Academic Journal
- Accession number :
- 19005641
- Full Text :
- https://doi.org/10.1007/s00125-008-1186-6