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A limited number of Bacillus subtilis strains carry a tetracycline-resistance determinant at a site close to the origin of replication.
- Source :
-
Biochimica et biophysica acta [Biochim Biophys Acta] 1991 Feb 16; Vol. 1088 (2), pp. 251-8. - Publication Year :
- 1991
-
Abstract
- Several strains of Bacillus subtilis, e.g., 168 derivatives and R, were found to carry a single copy of a tetracycline-resistance (TcR) determinant (named tetBS908) at a site close to the origin of replication on the chromosome. This gene is highly homologous (80% identical) to the TcR determinant of plasmids widely dispersed among aerobic spore-forming bacilli. B. subtilis RM125 (168 strain) transformants which carry a varying number of tetBS908 sequences in a tandem array on the chromosome were constructed and examined for their TcR level. A nearly proportional relationship between the TcR level and copy number of tetBS908 existed.
Details
- Language :
- English
- ISSN :
- 0006-3002
- Volume :
- 1088
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta
- Publication Type :
- Academic Journal
- Accession number :
- 1900438
- Full Text :
- https://doi.org/10.1016/0167-4781(91)90061-p