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Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes.
- Source :
-
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2009 Mar; Vol. 92 (1), pp. 39-43. Date of Electronic Publication: 2008 Oct 25. - Publication Year :
- 2009
-
Abstract
- Curcumin, a yellow pigment extracted from rhizomes of the plant Curcuma longa (turmeric), has been widely used as food additive and also as a herbal medicine throughout Asia. The present study was designed to study the pharmacological, biochemical and neurochemical effects of daily administration of curcumin to rats subjected to chronic unpredictable stress. Curcumin treatment (20 and 40 mg/kg, i.p., 21 days) significantly reversed the chronic unpredictable stress-induced behavioral (increase immobility period), biochemical (increase monoamine oxidase activity) and neurochemical (depletion of brain monoamine levels) alterations. The combination of piperine (2.5 mg/kg, i.p., 21 days), a bioavailability enhancer, with curcumin (20 and 40 mg/kg, i.p., 21 days) showed significant potentiation of its anti-immobility, neurotransmitter enhancing (serotonin and dopamine) and monoamine oxidase inhibitory (MAO-A) effects as compared to curcumin effect per se. This study provided a scientific rationale for the use of curcumin and its co-administration with piperine in the treatment of depressive disorders.
- Subjects :
- Animals
Biogenic Amines metabolism
Biological Availability
Biomarkers
Brain Chemistry drug effects
Brain Chemistry physiology
Chronic Disease
Cold Temperature
Depressive Disorder etiology
Female
Light
Monoamine Oxidase metabolism
Motor Activity drug effects
Rats
Rats, Wistar
Stress, Psychological complications
Stress, Psychological metabolism
Swimming psychology
Alkaloids pharmacology
Antidepressive Agents
Behavior, Animal drug effects
Benzodioxoles pharmacology
Curcumin pharmacology
Depressive Disorder drug therapy
Depressive Disorder psychology
Piperidines pharmacology
Polyunsaturated Alkamides pharmacology
Stress, Psychological psychology
Subjects
Details
- Language :
- English
- ISSN :
- 0091-3057
- Volume :
- 92
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pharmacology, biochemistry, and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 19000708
- Full Text :
- https://doi.org/10.1016/j.pbb.2008.10.007