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Osteonecrosis in children treated for lymphoma or solid tumors.
- Source :
-
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2008 Nov; Vol. 30 (11), pp. 798-802. - Publication Year :
- 2008
-
Abstract
- Purpose: The purpose of this study was to find out the incidence of and clinical risk factors for magnetic resonance imaging (MRI)-detected osteonecrosis (ON) in children treated for lymphoma or solid tumors.<br />Patients and Methods: The development of ON was studied in 32 childhood cancer patients who underwent MRI scanning of the lower extremities at the end of their treatment. The underlying malignancy was Wilms tumor in 8 patients, non-Hodgkin lymphoma (NHL) in 8, Hodgkin disease (HD) in 7, rhabdomyosarcoma in 6, and other occasional solid tumors in 3 patients.<br />Results: Six of the 32 patients (19%) had ON. The mean age of the patients with ON at diagnosis was 12.7 years compared with 5.8 years for the patients without ON (P<0.001). All the patients with ON had either HD (4 patients) or NHL (2 patients). Two (33%) of the patients with ON were symptomatic.<br />Conclusions: ON in MRI was found to be a common complication in children after treatment for HD or NHL. The risk for ON seems to be very low in patients with other solid tumors even when they receive high cumulative doses of dexamethasone.
- Subjects :
- Adolescent
Antineoplastic Combined Chemotherapy Protocols adverse effects
Child
Child, Preschool
Dexamethasone therapeutic use
Female
Hodgkin Disease pathology
Humans
Incidence
Lymphoma, Non-Hodgkin pathology
Magnetic Resonance Imaging
Male
Neoplasms pathology
Osteonecrosis diagnosis
Risk Factors
Hodgkin Disease drug therapy
Lymphoma, Non-Hodgkin drug therapy
Neoplasms drug therapy
Osteonecrosis chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1536-3678
- Volume :
- 30
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of pediatric hematology/oncology
- Publication Type :
- Academic Journal
- Accession number :
- 18989155
- Full Text :
- https://doi.org/10.1097/MPH.0b013e31818ab29d