Back to Search
Start Over
Herpesvirus-associated neurological disease in a donkey.
- Source :
-
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc [J Vet Diagn Invest] 2008 Nov; Vol. 20 (6), pp. 820-3. - Publication Year :
- 2008
-
Abstract
- A 4-year-old donkey was evaluated for progressive neurological abnormalities consisting of depression, stupor, weakness, and recumbency. Diagnostic evaluation for viral involvement identified an asinine herpesvirus in DNA extracted from deep pharyngeal swabs. Specific primers were designed based on comparison with equine herpesviral DNA polymerase sequences and yielded an 875-base pair product from the donkey. This sequence had complete identity with short sequences of asinine herpesvirus previously identified in donkeys with interstitial pneumonia. Amino acid analysis of the entire sequence indicated high similarity with Equid herpesvirus 7 (91%), Zebra herpesvirus 1 (90%), and Equid herpesvirus 2 (89%). With supportive treatment and physical therapy, the donkey gradually recovered over 5 days of hospitalization and returned to normal function. The current case illustrates the potential of a novel asinine herpesvirus to induce neurological disease in donkeys and provides a large viral sequence allowing confident assignment of this virus to the subfamily Gammaherpesvirinae.
- Subjects :
- Amino Acid Sequence
Animals
Base Composition
Conserved Sequence
DNA, Viral chemistry
DNA-Directed DNA Polymerase chemistry
DNA-Directed DNA Polymerase genetics
Equidae
Female
Herpesviridae classification
Herpesviridae genetics
Herpesvirus 1, Equid classification
Herpesvirus 1, Equid genetics
Herpesvirus 3, Equid classification
Herpesvirus 3, Equid genetics
Herpesvirus 3, Equid isolation & purification
Molecular Sequence Data
Phylogeny
Sequence Alignment
Viral Proteins chemistry
Viral Proteins genetics
Herpesviridae isolation & purification
Herpesviridae Infections veterinary
Herpesvirus 1, Equid isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1040-6387
- Volume :
- 20
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
- Publication Type :
- Academic Journal
- Accession number :
- 18987238
- Full Text :
- https://doi.org/10.1177/104063870802000620