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Association of the composite IL-1 genotype with peri-implantitis: a systematic review.
- Source :
-
Clinical oral implants research [Clin Oral Implants Res] 2008 Nov; Vol. 19 (11), pp. 1154-62. - Publication Year :
- 2008
-
Abstract
- Objective: Cytokine gene polymorphisms may modulate the host response to the bacterial challenge and influence susceptibility to peri-implantitis.<br />Objective: To systematically review the evidence of an association between the interleukin-1 (IL-1) composite genotype, i.e. presence of the allele 2 in the gene clusters IL-1A (-889) and in IL-1B (+3953), and peri-implantitis.<br />Material and Methods: An electronic search in the National Library of Medicine-computerized bibliographic database MEDLINE and a manual search were performed. The search was conducted for longitudinal clinical trials comparing progression of peri-implantitis in IL-1 genotype positive (carrying allele 2) with IL-1 genotype negative (not carrying allele 2) subjects. Selection of publications, extraction of data and validity assessment were made independently by two reviewers.<br />Results: The search provided 44 titles of which two longitudinal publications were included.<br />Conclusion: Based on the findings from this study, there is not enough evidence to support or refute an association between the IL-1 genotype status and peri-implantitis. Systematic genetic testing for the assessment of the risk of peri-implantitis cannot be recommended as a standard of care at this time.
Details
- Language :
- English
- ISSN :
- 1600-0501
- Volume :
- 19
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Clinical oral implants research
- Publication Type :
- Academic Journal
- Accession number :
- 18983319
- Full Text :
- https://doi.org/10.1111/j.1600-0501.2008.01596.x